ROLE OF MI-RNAS IN PANCREATIC CANCERS

Authors

  • Saleema Mehboob Ali Department of Surgery, Aga Khan University, Stadium Road, P. O. Box 3500 Karachi 74800
  • Yumna Adnan Department of Surgery, Aga Khan University, Stadium Road, P. O. Box 3500 Karachi 74800,
  • d S. M. Adnan Ali Department of Surgery, Aga Khan University, Stadium Road, P. O. Box 3500 Karachi 74800,

Keywords:

Genetic variants, Breast cancer, ATM, PTEN, BRCA2

Abstract

Pancreatic malignancy is one of the most lethal cancers that accounts for approximately 1000 annual
reported deaths in Pakistan. Diagnosis and treatment of pancreatic cancers remain challenging due to
complex anatomical location of pancreas, appearance of common symptoms and aggressive nature of
the tumor. Currently, only conventional treatment options are available in Pakistan that is surgery,
chemotherapy and/or radiotherapy. Recent studies around the globe have demonstrated mi-RNA as an
important biomarker for cancer diagnosis, prognosis prediction and treatment selection. In addition,
aberrant expression of mi-RNAs are also found to be associated with initiation, progression and
metastasis of various cancers including pancreatic cancers. This review aims to discuss role of
aberrantly expressed mi-RNAs in pancreatic cancers

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Published

2020-12-24

How to Cite

Saleema Mehboob Ali, Yumna Adnan, & d S. M. Adnan Ali. (2020). ROLE OF MI-RNAS IN PANCREATIC CANCERS. PAKISTAN JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 53(4), 101–115. Retrieved from http://www.pjbmb.com/index.php/pjbmb/article/view/8

Issue

Vol. 53 No. 4 (2020): PAKISTAN JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY

Section

Articles

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Copyright (c) 2020 PAKISTAN JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY

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