https://www.pjbmb.com/index.php/pjbmb/issue/feed 2026-09-13T11:47:22+00:00 Prof. Dr. M. Kamran Azim exeditor.pjbmb@gmail.com Open Journal Systems <div class="fw-row"> <div class="fw-col-xs-12"> <div class="seline-default-heading"> <p>The Pakistan Journal of Biochemistry and Molecular Biology (PJBMB) (ISSN P 1681-4525; ISSN E 2788-4147) is an open-access journal that publishes papers that contribute to knowledge in the field of Biochemistry, Molecular Biology, and related areas.</p> <p>PJBMB is currently published under the auspices of Mohammad Ali Jinnah University in Karachi, Pakistan.</p> <p>An article for publication must describe substantial original research undertaken according to the scope of this journal. A manuscript submitted for publication implies that the work described has not been published before (except as an abstract or a published lecture, review, or thesis). At the time of its submission to PJBMB it should neither be under consideration for publication elsewhere nor will it be reproduced after its publication in any other journal. Any co-authors must have agreed with the contents of the publication including the institution where the work was carried out. All authors should have agreed to the automatic transfer of copyright to the Editor-in-Chief of PJBMB.</p> <p>Since 1968, the Pakistan Journal of Biochemistry and Molecular Biology (PJBMB) has been consistently published as the official publication of the Pakistan Society of Biochemistry and Molecular Biology. As a result, it stands as one of the nation’s most longstanding scholarly periodicals.</p> <p>Since 2010, volumes of PJBMB is being published online (ISSN E 2788-4147). Recently, PJBMB has established online journal publishing with the help of "Open Journal Systems" (OJS). The OJS is an open-source software application for managing and publishing scholarly journals.</p> <p>PJBMB volumes published since 2018 to date are available online at pjbmb.com. Whereas, volumes published during 2010-2017 can be accessed at www.pjbmb.org.pk.</p> </div> </div> </div> https://www.pjbmb.com/index.php/pjbmb/article/view/161 2025-11-24T09:39:07+00:00 Muhammad Farhan farhankamali@uok.edu.pk Ayesha Mansoor farhankamali@uok.edu.pk Anila Bibi farhankamali@uok.edu.pk Ayesha Ahmed Soomro farhankamali@uok.edu.pk Shoaib Ahmed farhankamali@uok.edu.pk Atiqa Urooj farhankamali@uok.edu.pk Syeda Rabab Zehra farhankamali@uok.edu.pk Sehar Asif farhankamali@uok.edu.pk Jaweria Kanwer farhankamali@uok.edu.pk

<p>Neurodegenerative diseases are a broad category of neurological disorders with a variety of clinical and pathological manifestations that affect specific subsets of neurons in specific functional anatomic systems. Oxidative stress complicates the pathophysiology of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Oxidative stress is caused by redox imbalances, which include either excessive production of reactive oxygen species (ROS) or antioxidant system dysfunction. Due to its high oxygen demand and abundance of peroxidation-susceptible lipid cells, the central nervous system is vulnerable to the effects of ROS. Cadmium is a neurotoxin with a high toxicity level and toxicity of Cadmium can be exacerbated by nutritional deficiencies. We have analyzed the behavioral changes in rats after receiving Cadmium on a regular basis. The home cage activity test, open field test, elevated plus maze test, and force swim test were used to assess the behavioral consequences and impairments in learning and memory of male rats who were given Cadmium (1.0 mg/ml/kg, orally) or saline daily. In the elevated plus maze, Cadmium-treated rats exhibited depressive behavior, such as increased time spent immobile in the open field and increased anxiety-like behavior. With increased Cadmium administration, however, time spent in the lit box decreased. Results indicate that prolonged exposure of rats to Cadmium induced stress, which subsequently led to depressive behavior.</p>

2026-09-13T00:00:00+00:00 Copyright (c) 2026 PAKISTAN JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY https://www.pjbmb.com/index.php/pjbmb/article/view/160 2025-11-23T13:54:26+00:00 M. Kamran Azim exeditor.pjbmb@gmail.com

<p>Pakistan represents one of the most genetically diverse regions in South Asia, yet remains underrepresented in global genomic databases. The advent of long-read next-generation sequencing (NGS) technologies offers unprecedented opportunities to explore this diversity, resolve complex genomic structures, and address pressing health and agricultural challenges. This perspective highlights the potential of long-read sequencing in advancing Pakistani genomics, with <br>implications for medicine, population genetics, and sustainable development.</p>

2026-09-13T00:00:00+00:00 Copyright (c) 2025 PAKISTAN JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY